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Ofloxacin (Tarivid)
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Description
A quinolone antibiotic.
Indications
Used to treat urinary tract infections and gonorrhoea.
Effects on oral and dental structures
This drug can cause candidiasis, xerostomia, taste disturbance and
Stevens–Johnson syndrome.
Effects on patient management
Antifungal therapy may be required if oral candidiasis occurs. As the
drug is only used short term xerostomia should not produce significant
problems, however a preventive regimen may be considered. This drugmay cause thrombocytopenia, leucopenia, and anaemia. Thrombocytopenia
may cause postoperative bleeding. If the platelet count is low
(100,000) then the socket should be packed and sutured. Persistent
bleeding may require platelet transfusion. Leucopenia and anaemia
may result in poor healing. Any anaemia will need correction prior to
elective general anaesthesia and sedation.
Drug interactions
This drug increases the anticoagulant effect of warfarin and nicoumalone.
Combined therapy with non-steroidal anti inflammatory
drugs increases the risk of convulsions.
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